Anabolic steroids are drugs that resemble androgenic hormones (also called male hormones), such as testosterone. Athletes use them in the hope to increase the weight, strength, power, speed, endurance, and aggressiveness. Many athletes believe that without anabolic steroids they would not be so successful. Anabolic steroids are divided into two types - injectable and oral. Oral steroids have a very short shelf life and create an unnecessary burden on the liver. Injectable steroids front, safer and have long half-life, which increases their life span. It should also be noted that, despite the great variety of anabolic drugs, synthetic base from which to create these drugs with modified properties, quite a bit. They usually come in a group called "derivatives" of any steroids.
Anabolic steroids stimulate the receptor molecules in muscle cells, which activate specific genes to produce proteins. Anabolic steroids also affect the rate of activation of enzyme systems involved in the metabolism of proteins, thereby increasing protein synthesis and preventing its degradation (anti-catabolic effect). They also contribute to delay fatigue and can produce feelings of euphoria. Androgenic effect - a change of secondary sexual characteristics. These include voice changes, increased hair growth and increased aggression. Anabolic effects of androgens include accelerated growth of muscle, bone, red blood cells and an increase in neural conduction. There have been quite a few attempts to separate the anabolic effects of hormones on their androgenic effect, but only managed to reduce the second. Essentially, steroids strongest anabolic effect, have the strongest androgenic. That is why, potent anabolic androgenic substances can cause side effects, especially if used for a long period.
As you know, all drugs have their life span and life, including anabolic steroids. For clarity, we take testosterone cypionate, the half-life of approximately 12 days. Suppose you enter 1000 mg cypionate. This means that 12 days after the last injection, testosterone cypionate blood will be 500 mg. At the expiration of yet another 12 days, that is 24 days after the last injection, the rate drops to 250 mg and so on. So, after each period to take exactly half of the remaining level of drug in the blood. When you enter a drug before the expiration of the 12 days, plus leftovers.
That is why, the hormone levels are usually only grows with each new dose. When you complete the course and did not put any drugs in your blood are still "active" steroids, which continue to have the desired effect (it all depends on the dose and half-life). It may take a few of these half-lives, the active substance is completely taken out of the body.
Esterification temporarily deactivates the steroid molecule. When esters block 17th position associated with the androgen receptor is not possible. For connections are accessible only to ether, which must first be removed to get to the steroid. Everything happens automatically - once the connection seeps into the blood esterases cleave quickly prevents air. Only then will an anabolic effect and will show all the advantages.
When you make an injection, the drug forms a depot (the injection site) in muscle tissue, where anabolic gradually into the bloodstream. Therefore, the longer the carbon chain, the less soluble drug and the longer half-life. There is a process very similar to the esterification - alkylation. He just called to prolong the life of anabolic steroids, not injected, and oral (tablets) and for a few hours (instead of minutes). Liver becomes difficult to handle such modified steroids and, thus, oral steroids make several cycles through the bloodstream before complete withdrawal.
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